Who Counters Iseria in Epic Seven?

Swift Flagbearer Sigret, Witch of the Mere Tenebria, Unbound Knight Arowell and other hard counters counter Iseria. Her value lives in debuffs, namely Defense Down and Unbuffable. A target that resists the application, or that holds an immunity buff before Full Bloom lands, shrugs off the lockdown and keeps its protections intact.

Effect resistance and immunity: Her value lives in debuffs, namely Defense Down and Unbuffable. A target that resists the application, or that holds an immunity buff before Full Bloom lands, shrugs off the lockdown and keeps its protections intact. Cleansing and debuff-shortening support: Because she works one enemy at a time, an enemy healer or supporter that cleanses the Unbuffable and Defense Down, or shortens their duration, undoes her setup before your follow-up arrives. Long cooldowns on her key skills: Oathkeeper has a 6-turn cooldown and Full Bloom a 5-turn cooldown, so she can only enable an ally or perform her buff-strip every several turns; between uses she has little to offer but a single-target basic, leaving gaps a fast team can exploit. Single-target reach against wide teams: She affects only one enemy at a time and has no passive, so against a team that spreads its buffs and threats across multiple units she can neutralize just one of them, leaving the rest free to act.

Heroes propped up by buffs or shields: Full Bloom dispels every buff on its target and then locks the enemy as Unbuffable for 2 turns, so a unit relying on stacked attack buffs, an immunity buff, or a protective barrier loses those layers and cannot simply re-apply them on its next turn. Defensive bruisers and tanky targets: Both her basic attack and Full Bloom apply Decrease Defense, so a high-Defense wall takes far more damage from Iseria and from the ally she empowers, eroding the survivability that target depends on. Slow or one-shot allied carries: Oathkeeper resets an ally's cooldown and grants Greater Attack, letting a strong nuker land its biggest skill again immediately at boosted damage; against an enemy that survived the first hit, the second empowered strike often finishes the job. Hard-to-kill front-liners that must be opened first: Stripping buffs, denying re-buffing, and shredding Defense on a single priority target sets up your team to burst down a key threat before it can stabilize, since the Unbuffable window stops it from refreshing its defenses or healing into fresh buffs.